The objective of the present investigation is to formulate gastro retentive floating drug delivery systems (GRFDDS)\r\nof propranolol HCl by central composite design and to study the effect of formulation variables on floating lag\r\ntime, D1hr (% drug release at 1 hr) and t90 (time required to release 90% of the drug). 3 factor central composite\r\ndesign was employed for the development of GRFDDS containing novel semi synthetic polymer carboxymethyl\r\nethyl cellulose (CMEC) as a release retarding polymer. CMEC, sodium bicarbonate and Povidone concentrations\r\nwere included as independent variables. The tablets were prepared by direct compression method and were\r\nevaluated for in vitro buoyancy and dissolution studies. From the polynomial model fitting statistical analysis, it was\r\nconfirmed that the response floating lag time and D1hr is suggested to quadratic model and t90 is suggested to\r\nlinear model. All the statistical formulations followed first order rate kinetics with non-Fickian diffusion mechanism.\r\nThe desirability function was used to optimize the response variables, each having a different target, and the\r\nobserved responses were highly agreed with experimental values. Statistically optimized formulation was\r\ncharacterized by FTIR and DSC studies and found no interactions between drug and polymer. The results\r\ndemonstrate the feasibility of the model in the development of GRFDDS containing a propranolol HCl. Statistically\r\noptimized formulation was evaluated for in vivo buoyancy studies in healthy humans for both fed and fasted\r\nstates. From the results, it was concluded that gastric residence time of the floating tablets were enhanced at fed\r\nstage but not in fasted state
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